What Is Lupron?
Traditionally, leuprolide (Lupron) has been used to treat advanced prostate cancer, endometriosis, uterine fibroids, and premature puberty. With Assisted Reproductive Technology (ART), Lupron is used differently. Dosage, strength, shelf life, and how it is supplied will vary depending on the type of IVF treatment prescribed.
Using Microdose Flare Lupron
Who It’s For
Microdose Flare Lupron is generally used for patients who may respond poorly to IVF stimulation medications, such as those with low ovarian reserve or advanced maternal age.
How It Works
The idea is to use Lupron at a low dose to stimulate a release of FSH in the body. Combined with FSH stimulation medications, this helps the ovaries produce more eggs. Microdose Lupron is compounded (made to order) and typically has a shelf life of 9 to 30 days.
When It’s Taken
It is usually started on day 2 of the menstrual cycle and is administered as an injection once in the morning and again in the evening.
Lupron as a Trigger Shot
One of the most common protocols uses Lupron as a trigger instead of hCG to mature follicles before egg collection. The use of Lupron significantly reduces the risk of Ovarian Hyperstimulation Syndrome (OHSS).
Why It’s Effective
Lupron causes a short-lived LH surge that matures the eggs for IVF. It clears from the body quickly, reducing prolonged ovarian stimulation—unlike hCG, which lingers in the system.
Why We Freeze All Embryos
Because Lupron causes a rapid drop in estradiol and progesterone levels, luteal phase support decreases. To ensure optimal timing and uterine readiness, all embryos are cryopreserved and transferred in a frozen embryo transfer (FET) cycle the following month. This also allows time for genetic testing of embryos if desired.
Lupron in Frozen Embryo Transfer Cycles
Lupron is also commonly used in frozen embryo transfer cycles. It’s used during the luteal phase of the prior cycle to suppress ovarian activity and prevent ovulation.
Step-by-Step Timing
Lupron typically continues throughout the FET cycle and is stopped one week before progesterone is introduced. This protocol helps mimic a natural cycle with hormonal support: estradiol thickens the uterine lining, and progesterone prepares it for implantation.
Why Lupron Has Many Applications
Lupron is a versatile medication used in several fertility treatment protocols, depending on the patient’s needs and the desired outcomes. It may be prescribed in different doses and schedules across various cycles. If you’re unsure why Lupron is part of your plan, don’t hesitate to ask your care team.
Schedule a consultation to learn more about your personalized treatment options and how medications like Lupron support your fertility journey.
