ICSI is a specialized procedure used with IVF

Intracytoplasmic Sperm Injection

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What is ICSI?

Intracytoplasmic Sperm Injection (ICSI) is a specialized procedure used in In Vitro Fertilization (IVF) to treat male infertility. In this process, a single sperm is directly injected into an egg to facilitate fertilization. ICSI is particularly useful in cases where male factor infertility is an issue, such as low sperm count, poor sperm mobility, or when sperm are unable to fertilize an egg naturally. This technique enhances the likelihood of fertilization and is often used when previous IVF attempts have been unsuccessful or when sperm must be retrieved surgically.

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cutting edge fertility treatment for male infertility

The Pinnacle Difference

  • Direct Injection of Sperm: In ICSI, a single sperm is injected directly into an egg. This is different from traditional IVF, where multiple sperms are placed with an egg in a dish for fertilization to occur.
  • Treatment for Male Infertility: ICSI is particularly useful in situations where male infertility is a factor. This includes low sperm count, poor sperm mobility, or sperm that are otherwise unable to fertilize an egg naturally.
  • Use of Retrieved Sperm: Sperm used in ICSI can be obtained from ejaculate or, in cases where sperm count is extremely low, directly from the testicles through a surgical procedure.
  • Higher Fertilization Rates: By injecting the sperm directly into the egg, ICSI can achieve fertilization in cases where traditional IVF might not be successful.
  • Widely Used with IVF: ICSI has become a common part of the IVF process, particularly in cases where there is a known issue with sperm quality or quantity.
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Matching Patients with ICSI Solutions

Who Is ICSI Right For?

ICSI at Pinnacle may be right for many couples and singles facing specific fertility challenges, including:

  • Male Factor Infertility: ICSI is ideal for men with low sperm count, poor sperm motility (movement), or abnormal sperm shape (morphology). It's also used in other cases where sperm are unable to penetrate the egg without assistance.
  • Previous IVF Failure: Couples who have had unsuccessful IVF cycles may benefit from ICSI. It can improve the chances of fertilization if previous attempts resulted in low fertilization rates or no fertilization.
  • Obstructive Azoospermia: Men who have no sperm in their ejaculate due to a blockage (e.g., vasectomy, congenital absence of the vas deferens) can benefit from ICSI. Sperm can be surgically extracted from the testicles or epididymis for use in the procedure.
  • Non-Obstructive Azoospermia: In cases where there's a very low sperm production, ICSI can be used with sperm obtained through a biopsy of the testes.
  • Frozen Sperm Use: ICSI is useful when frozen sperm is being used, especially if there's a limited quantity or quality of sperm after thawing.
  • Egg Quality and Age Factors: For older women or those with a history of poor egg quality, ICSI can maximize the chances of fertilization by directly injecting the sperm into the egg.


Yes, ICSI can be effectively used with both frozen eggs and sperm. It is particularly useful in cases where sperm viability might be compromised due to the freezing and thawing process.

The risks associated with ICSI are similar to those of IVF and include ovarian hyperstimulation syndrome, multiple pregnancies, and the potential for ectopic pregnancy. There's also a slightly increased risk of birth defects, though this is relatively low.

ICSI success rates depend on various factors, including egg quality, the underlying cause of infertility, and the overall health of the couple. Generally, ICSI success rates are comparable to those of traditional IVF.

ICSI is a specialized form of IVF where a single sperm is directly injected into an egg. While traditional IVF involves mixing multiple sperms with an egg, ICSI is used particularly for cases of severe male infertility, as it requires only one viable sperm per egg.

Real Stories, Real Success: Our Patients Speak

Jesus C.

We can't thank you all enough for making our IVF journey such a positive experience. Your team's expertise and warmth meant the world to us. You made our dreams come true, and we're forever thankful.

California Fertility Partners
Los Angeles, CA
Krista B.

THEY ARE AMAZING!!! I absolutely love this clinic and everyone who works here! Being a lesbian couple, we were nervous trying to find a fertility clinic for us.. they made us feel so comfortable right away! They are so caring and sweet! I definitely recommend this place!! && Dr. Z is the man!! Nicest doctor I have ever met! I would give them a 100 stars if I could!

Advanced Fertility Care
Scottsdale, AZ
Patrick P.

Thanks to Dr. Dudley, we achieved a successful pregnancy, a dream that once seemed unattainable. His expertise and empathy made him not just a doctor but a beacon of hope in our most challenging times. We are profoundly grateful to Dr. Dudley and highly recommend him to any couple facing fertility issues!

Pinnacle Fertility
Atlanta, GA
Lee B.

We've worked with RGI twice now, and have had an excellent experience both times. Dr. Maseelall and her team have been amazing to work with. This time around, we were introduced to the "navigators" who essentially act as a liaison between us and the doctors, which was a change from the last time we were there. We found having access to a dedicated resource - even by text message - was a huge plus.

Reproductive Gynecology & Infertility
Akron, OH

I highly recommend Dr. Dudley! He is one of the only doctors who explained things clearly, realistically, and positively. His bedside manner is outstanding. A defining moment (without disclosing my medical history) was when I explained something to him and he responded with "I believe in a women's intuition." He believed me, ran a quick test, and pivoted the plan. I can't recommend him enough.

Pinnacle Fertility
Atlanta, GA
Diana M.

My husband I went to Dominion after struggling with some fertility issues and multiple miscarriages. We couldn't have made a better choice! You can tell that the staff really care about their patients and make you feel at ease. At the beginning of the process, we were feeling a bit overwhelmed, but the doctors were understanding and great at explaining each step to us along the way. We now have a healthy baby boy and we could not be more happy and grateful to Dominion Fertility!!

Dominion Fertility
Arlington, VA